It is said that the discovery and use of antibiotics against infectious diseases is one of the developments in the field of medicine that has contributed about twenty years to the average lifespan of humans in developed countries where these practices are employed. Yet, based on the 35 million patients admitted to the acute-care institutions in the US, the incidence of hospital-acquired infections is more than two million cases per year. Burke Cunha explores this important topic in this timely new issue of Critical Care Clinics. Including articles on Antibiotic Therapy of IV Central Line, Tigecycline in Critical Care, and Antibiotic Resistance: Prevention and Control in Critical Care, this issue is a must-have reference for any clinician in the critical care field.